Glycogen Storage Disease (GSD) > 자유게시판

Such a scheme serves as a template for the lactate shuttling current within the mammalian CNS. An virtually contemporaneous report extended this scheme to use to the mammalian mind, but with notable differences and additions. It was to show one of the crucial contentious papers in the sector of brain power metabolism and the controversy raging around the topic persists. The paper described experiments carried out using cultures of mouse cerebral neurones and Healthy Flow Blood astrocytes, and demonstrated a few key options, Healthy Flow Blood site which have been stoichiometrically strong (Pellerin and Healthy Flow Blood site Magistretti, 1994). The background to the study was the realization that if metabolic signaling had been to occur between neurones and astrocytes within the mammalian CNS, Healthy Flow Blood site there must exist a signaling mechanism whereby the neurones signal to astrocytes their need for supply of metabolic substrate. The signaling mechanism should have the following traits: (1) it should be related to the frequency of exercise of the neurones i.e., the discharge of the compound must be associated to the exercise of the neurones, (2) it should be sensed by the astrocyte i.e., there should be mechanism(s) whereby the astrocyte senses the molecule, and (3) there must exist a system or course of whereby the concentration of the molecule is decreased upon cessation of activity i.e., Healthy Flow Blood site there have to be an efficient buffering system that reduces the focus of the molecule after activity.

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